J Clin Med 12(18):6052 Tsapas A, Karagiannis T, Kakotrichi P, Avgerinos I, Mantsiou C, Tousinas G, Manolopoulos A, Liakos A, Malandris K, Matthews DR, Bekiari E (2021) Comparative efficacy of glucose-lowering medications on body weight and blood pressure in patients with type 2 diabetes: a systematic review and network meta-analysis
Insert the needle with firm, steady pressure at a slight angle
Modified-release (MR) preparations are an option when standard metformin causes gastrointestinal side effects
But if you accidentally inject two doses one day apart, or forget which day you are on and double up, the resulting concentration spike can cause significant side effects including severe nausea, gastrointestinal distress , and potentially hypoglycemia in those also taking diabetes medications